Stage 2: Silent

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在2018年3月13日 (二) 17:29由Guhjy (對話 | 貢獻)所做的修訂版本
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2-3rd year 40% progress to stage 3 Pathology

  • Thick GBM
    • Heparan sulfate lost
      • Loss of charge selectivity for proteins
        • Proteinuria or albuminuria
  • Mesangial expansion or sclerosis
    • Pathogenesis
    1. Glomerular hypertension
    2. Proteinuria
    3. Advanced glycosylation end products ↑
    4. Growth hormone ↑
    5. IGF-I ↑
    6. Angiotensin II ↑
    7. Connective tissues growth factor ↑
    8. Transforming growth factor-β
    9. Hyperlipidemia