Stage 2: Silent

出自KMU Wiki

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2-3rd year 40% progress to stage 3

  • Pathology
    • Thick GBM
    • Heparan sulfate lost
      • Loss of charge selectivity for proteins
        • Proteinuria or albuminuria
    • Mesangial expansion or sclerosis
  • Pathogenesis
    • Glomerular hypertension
    • Proteinuria
    • Advanced glycosylation end products ↑
    • Growth hormone ↑
    • IGF-I ↑
    • Angiotensin II ↑
    • Connective tissues growth factor ↑
    • Transforming growth factor-β
    • Hyperlipidemia
取自"http://wiki.kmu.edu.tw/index.php/Stage_2:_Silent"