Infective endocarditis

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Also called "subacute bacterial endocarditis"
Endocarditis-associated GN occurs in patients who remain untreated for a long time (>10-14 days), have negative blood cultures, or have right-sided endocarditis.
Anemia, ESR ↑, hematuria, proteinuria, aGN, RPGN (rare), pyuria, renal failure
Pathology (focal proliferative GN)
- Grossly, the kidneys have subcapsular hemorrhages with a "flea-bitten" appearance
- Focal proliferation around foci of necrosis associated with abundant mesangial, subendothelial, and subepithelial immune deposits of ~IgG, ~IgM, and C3
  - Embolic renal infarction or septic abscess
Complement ↓, RA factor, cryoglobulin, circulating immune complex
Prognosis
- Good if resolve after treatment with antibiotics for 4-6 weeks