Stage 2: Silent
出自KMU Wiki
2-3rd year 40% progress to stage 3 Pathology
- Thick GBM
- Heparan sulfate lost
- Loss of charge selectivity for proteins
- Proteinuria or albuminuria
- Loss of charge selectivity for proteins
- Heparan sulfate lost
- Mesangial expansion or sclerosis
- Pathogenesis
- Glomerular hypertension
- Proteinuria
- Advanced glycosylation end products ↑
- Growth hormone ↑
- IGF-I ↑
- Angiotensin II ↑
- Connective tissues growth factor ↑
- Transforming growth factor-β
- Hyperlipidemia