Light chain deposition disease

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Light chain-producing monoclonal gammapathies (Paraproteinemia)
Nephrotic syndrome
Hematuria
Renal failure
ESRD
Pathology
- κ light chains deposit in the glomerular capillary and mesangium (to produce nephrotic syndrome), tubular basement membrane, and Bowman's capsule
  - Not fibrillar and do not stain with Congo red, detected with anti-light–chain antibody using immunofluorescence, or as granular deposits along the glomerular capillary (causing nephrotic syndrome) and mesangium, tubular basement membrane, and Bowman's capsule
- Nodular glomerulosclerosis (33%)
- Tubular abnormalities
Poor prognosis esp. if Multiple myeloma
Treatment (for underlying dis.)