Henoch-Schönlein purpura

出自KMU Wiki

• Clinical features
  • Young (<20 y/o), palpable purpura, abdominal pain, GI bleeding, arthropathy, fever, fatigue, ~IgA ↑ (50% p’ts), hematuria, proteinuria, macroscopic hematuria immediately after URI in children, NS (uncommon)
  • GN is very similar to ~IgA nephropathy
  • Skin: Leukocytoclastic vasculitis, dermal ~IgA deposits
• Kidney biopsy is indicated only for p’ts with marked proteinuria or renal failure
• Treatment
  • Similar to ~IgAN
  • Corticosteroids or cytotoxics for RPGN
• Prognosis
  • Good (esp. in children), chronic renal failure & hypertension (rare)
• References of Henoch-Schönlein purpura