Atherosclerotic nephropathy

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  • Risk factors
    • Aging, obesity, insulin resistance, smoking, hypertension, hyperlipidemia
    • Apolipoprotein E gene polymorphism
      • Lipoprotein glomerulopathy
  • CKD patients with GFR<60 mL/min have more cardiovascular events and hospitalizations than those with higher filtration rates
  • Approximately 10% of glomeruli are normally sclerotic by age 40, rising to 20% by age 60 and 30% by age 80