Amyloidosis

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  • Diagnosed by abdominal fat pad, rectal or kidney biopsy
  • Congo red-positve deposits in blood vessels and glomerular mesangium
  • Green birefringence under polarized light
  • Amyloid fibril + P component (α1-glycoprotein)
  • Classification
    • AL (amyloid L) amyloidosis
    • AA (amyloid A) amyloidosis
    • Alzheimer’s dis.
      • Senile dementia
    • Down’s syndrome
      • Amyloid β
    • Dialysis-associated
      • β2-microglobulin
    • Renal amyloidosis
  • References of amyloidosis