Guhjy: 新頁面: Antibody to anionic phospholipids, particularly ''β2 glycoprotein 1'' Diagnostic criteria **Presence in the serum of at least one type of autoantibody known as an antiphospholipid ...

Guhjy — Tue, 13 Mar 2018 09:47:06 GMT

新頁面: *Antibody to anionic phospholipids, particularly ''β2 glycoprotein 1'' *Diagnostic criteria **Presence in the serum of at least one type of autoantibody known as an antiphospholipid ...

新頁面

*Antibody to anionic phospholipids, particularly ''β2 glycoprotein 1''
*Diagnostic criteria
**Presence in the serum of at least one type of autoantibody known as an antiphospholipid antibody, which is directed against phospholipid-binding plasma proteins
**The occurrence of at least one clinical feature from a diverse list of potential disease manifestations, the most common of which are categorized as venous or arterial thromboses, pregnancy morbidity, or thrombocytopenia
*Idiopathic, pregnancy, hemodialysis, RT, GN (minimal change disease, membranous nephropathy), SLE (lupus anticoagulant with activated partial tissue thromboplastin time ↑)
*Clinical features
**Hematuria, proteinuria
**[[Vasculitis]]
***Treated by corticosteroids
**Severe form: hemolytic anemia, deep vein thrombosis, transient ischemic attacks, pulmonary embolism, spontaneous abortions
***<10% present have catastrophic multi-organ involvement and acute renal failure
***''Patients who present with acute flank pain and renal vein thrombosis in the setting of proteinuria should always be checked for antiphospholipid antibodies''
**Less severe form
**P'ts can wax and wane, and many patients have recurrences
*Thrombotic microangiopathy of the kidneys (25%)
**Affects interlobular artery, arterioles and glomerular capillaries
**Microthrombi
**Endotheliosis (also seen in preeclampsia/HELLP [hemolysis, elevated liver enzymes, and low platelet count syndrome], malignant hypertension)
**Treatment
***Warfarin
***[[Plasmapheresis]] and immunosuppresives for acute renal failure

Antiphospholipid syndrome - 修訂歷史

Guhjy: 新頁面: *Antibody to anionic phospholipids, particularly ''β2 glycoprotein 1'' *Diagnostic criteria **Presence in the serum of at least one type of autoantibody known as an antiphospholipid ...

Guhjy: 新頁面: Antibody to anionic phospholipids, particularly ''β2 glycoprotein 1'' Diagnostic criteria **Presence in the serum of at least one type of autoantibody known as an antiphospholipid ...