Pre-clinical (normoalbuminuria)

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在2018年3月27日 (二) 12:51所做的修訂版本 (編輯)
Guhjy (對話 | 貢獻)

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當前修訂版本 (2018年3月27日 (二) 17:09) (編輯) (撤銷)
Guhjy (對話 | 貢獻)

 
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第3行: 第3行:
*Mesangial expansion/sclerosis (PAS+) *Mesangial expansion/sclerosis (PAS+)
*Pathogenesis *Pathogenesis
-**Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-&beta, hyperlipidemia+**Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-β, hyperlipidemia

當前修訂版本

  • Urinary albumin excretion< 30 mg/g creatinine
  • < 5 year, renal hypertrophy, hyperfiltration, intrarenal hypertension, thick GBM (cannot predict progression), loss of heparan sulfate (negative charge)-->albuminuria
  • Mesangial expansion/sclerosis (PAS+)
  • Pathogenesis
    • Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-β, hyperlipidemia