Light chain deposition disease

出自KMU Wiki

跳轉到: 導航, 搜索
  • Light chain-producing monoclonal gammapathies (Paraproteinemia)
  • Nephrotic syndrome
  • Hematuria
  • Renal failure
  • ESRD
  • Pathology
    • κ light chains deposit in the glomerular capillary and mesangium (to produce nephrotic syndrome), tubular basement membrane, and Bowman's capsule
      • Not fibrillar and do not stain with Congo red, detected with anti-light–chain antibody using immunofluorescence, or as granular deposits along the glomerular capillary (causing nephrotic syndrome) and mesangium, tubular basement membrane, and Bowman's capsule
    • Nodular glomerulosclerosis (33%)
    • Tubular abnormalities
  • Poor prognosis esp. if Multiple myeloma
  • Treatment (for underlying dis.)