Infective endocarditis

出自KMU Wiki

• Also called "subacute bacterial endocarditis"
• Endocarditis-associated GN occurs in patients who remain untreated for a long time (>10-14 days), have negative blood cultures, or have right-sided endocarditis.
• Anemia, ESR ↑, hematuria, proteinuria, aGN, RPGN (rare), pyuria, renal failure
• Pathology (focal proliferative GN)
  • Grossly, the kidneys have subcapsular hemorrhages with a "flea-bitten" appearance
  • Focal proliferation around foci of necrosis associated with abundant mesangial, subendothelial, and subepithelial immune deposits of ~IgG, ~IgM, and C3
    • Embolic renal infarction or septic abscess
• Complement ↓, RA factor, cryoglobulin, circulating immune complex
• Prognosis
  • Good if resolve after treatment with antibiotics for 4-6 weeks