Pre-clinical (normoalbuminuria)

出自KMU Wiki

• Urinary albumin excretion< 30 mg/g creatinine
• < 5 year, renal hypertrophy, hyperfiltration, intrarenal hypertension, thick GBM (cannot predict progression), loss of heparan sulfate (negative charge)-->albuminuria
• Mesangial expansion/sclerosis (PAS+)
• Pathogenesis
  • Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-&b, hyperlipidemia