Stage 1: Hyperfiltration
出自KMU Wiki
- Glomerular hypertrophy & glomerular (inrarenal) hypertension
- Pathogenesis
- Hyperglycemia
- Angiotensin II ↑ (preferential efferent arteriole constriction)
- Atrial natriuretic peptide ↑
- Insulin-like growth factor I (~IGF-I) ↑
- Pathogenesis
- Tubular hypertrophy
- Renal hypertrophy