Introduction of diabetic nephropathy

出自KMU Wiki

• The most common cause of incident ESRD and the 2nd commonest cause of prevalent ESRD in Taiwan
• Prevalence
  • 40% in type 1 and 2 DM
  • Because type 2 DM is much more common than type 1 DM, most diabetic nephropathy patients have type 2 DM
• Importance of hyperglycemia in DN
  • DCCT (Diabetes Control and Complications Trial)
    • Type 1 DM
    • [1993;329:977: The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus]
  • UKPDS (UK Prospective Diabetes Study)
    • [1998;352:837: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)|]
    • Type 2 DM
  • Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain