Introduction of diabetic nephropathy

出自KMU Wiki

• The most common cause of incident ESRD and the 2nd commonest cause of prevalent ESRD in Taiwan
• Prevalence
  • 40% in type 1 and 2 DM
  • Because type 2 DM is much more common than type 1 DM, most diabetic nephropathy patients have type 2 DM
• Importance of hyperglycemia in DN
  • DCCT (Diabetes Control and Complications Trial)
    • Type 1 DM
    • NEJM 1993;329:977: [Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus]
  • UKPDS (UK Prospective Diabetes Study)
    • Type 2 DM
  • Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain