Introduction of diabetic nephropathy

出自KMU Wiki

• The most common cause of incident ESRD and the 2nd commonest cause of prevalent ESRD in Taiwan
• Prevalence
  • 40% in type 1 and 2 DM
  • Because type 2 DM is much more common than type 1 DM, most diabetic nephropathy patients have type 2 DM
• Importance of hyperglycemia in DN
  • DCCT (Diabetes Control and Complications Trial)
    • Type 1 DM
    • NEJM 1993;329:977: http://content.nejm.org/cgi/content/short/329/14/977
  • UKPDS (UK Prospective Diabetes Study)
    • Type 2 DM
    • Lancet 1998;352:837: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-3TX4KPJ-3&_user=2411013&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000051939&_version=1&_urlVersion=0&_userid=2411013&md5=6ce6fc1e30dcd65072e0b0bc72934dff
  • Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain