Pre-clinical (normoalbuminuria)

出自KMU Wiki

在2018年3月27日 (二) 12:59所做的修訂版本 (編輯) Guhjy (對話 | 貢獻) ←上一個		當前修訂版本 (2018年3月27日 (二) 17:09) (編輯) (撤銷) Guhjy (對話 | 貢獻)
第3行：		第3行：
	*Mesangial expansion/sclerosis (PAS+)		*Mesangial expansion/sclerosis (PAS+)
	*Pathogenesis		*Pathogenesis
-	**Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor- &beta, hyperlipidemia	+	**Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-β, hyperlipidemia

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當前修訂版本

• Urinary albumin excretion< 30 mg/g creatinine
• < 5 year, renal hypertrophy, hyperfiltration, intrarenal hypertension, thick GBM (cannot predict progression), loss of heparan sulfate (negative charge)-->albuminuria
• Mesangial expansion/sclerosis (PAS+)
• Pathogenesis
  • Glomerular hypertension, hyperfiltration, proteinuria, hyperglycemia, advanced glycosylation end products, growth hormone, atrial natriuretic peptide, insulin-like growth factor I, angiotensin II (efferent arteriole constriction), connective tissues growth factor, transforming growth factor-β, hyperlipidemia