Cryoglobulinemia

出自KMU Wiki

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當前修訂版本

• Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins
• May be associated with vasculitis
  • Palpable purpura, arthralgias, weakness, neuropathy, MPGN, RPGN (rare)
  • Rheumatoid factor (may be a surrogate for cryoglobulin), complement ↓, ESR ↑, anemia
  • Idiopathic
    • Also called "essential mixed cryoglobulinemia"
    • Mostly due to HCV infection
    • 5% of ~HCV-infected p'ts have "essential mixed cryoglobulinemia"
    • MPGN
      • ESRD (15%)
        • 40% later experiencing fatal cardiovascular disease, infection, or liver failure
    • Treatment for HCV (α-interferon)
  • Secondary
    • Multiple myeloma, lymphoproliferative disorders, connective tissue diseases, infection, liver disease