Cryoglobulinemia

出自KMU Wiki

在2018年3月14日 (三) 09:48所做的修訂版本 (編輯) Guhjy (對話 | 貢獻) (新頁面: *Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins *May be associated with vasculitis **Palpable purpura, arthralgias, weakness, neuropathy, MPGN, RPGN (rar...) ←上一個

當前修訂版本 (2018年3月14日 (三) 09:48) (編輯) (撤銷) Guhjy (對話 | 貢獻) (新頁面: *Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins *May be associated with vasculitis **Palpable purpura, arthralgias, weakness, neuropathy, MPGN, RPGN (rar...)

---

當前修訂版本

• Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins
• May be associated with vasculitis
  • Palpable purpura, arthralgias, weakness, neuropathy, MPGN, RPGN (rare)
  • Rheumatoid factor (may be a surrogate for cryoglobulin), complement ↓, ESR ↑, anemia
  • Idiopathic
    • Also called "essential mixed cryoglobulinemia"
    • Mostly due to HCV infection
    • 5% of ~HCV-infected p'ts have "essential mixed cryoglobulinemia"
    • MPGN
      • ESRD (15%)
        • 40% later experiencing fatal cardiovascular disease, infection, or liver failure
    • Treatment for HCV (α-interferon)
  • Secondary
    • Multiple myeloma, lymphoproliferative disorders, connective tissue diseases, infection, liver disease