Introduction of diabetic nephropathy

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	**DCCT (Diabetes Control and Complications Trial)		**DCCT (Diabetes Control and Complications Trial)
	***Type 1 DM		***Type 1 DM
-	***[http://content.nejm.org/cgi/content/short/329/14/977| NEJM 1993:329:977. The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus]	+	***[http://content.nejm.org/cgi/content/short/329/14/977| NEJM 1993;329:977. The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus]
	**UKPDS (UK Prospective Diabetes Study)		**UKPDS (UK Prospective Diabetes Study)
-	*** [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-3TX4KPJ-3&_user=2411013&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000051939&_version=1&_urlVersion=0&_userid=2411013&md5=6ce6fc1e30dcd65072e0b0bc72934dff| Lancet 1998:352:837. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)]	+	*** [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-3TX4KPJ-3&_user=2411013&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000051939&_version=1&_urlVersion=0&_userid=2411013&md5=6ce6fc1e30dcd65072e0b0bc72934dff| Lancet 1998;352:837. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)]
	***Type 2 DM		***Type 2 DM
	**Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain		**Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain

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在2018年3月13日 (二) 17:24所做的修訂版本

• The most common cause of incident ESRD and the 2nd commonest cause of prevalent ESRD in Taiwan
• Prevalence
  • 40% in type 1 and 2 DM
  • Because type 2 DM is much more common than type 1 DM, most diabetic nephropathy patients have type 2 DM
• Importance of hyperglycemia in DN
  • DCCT (Diabetes Control and Complications Trial)
    • Type 1 DM
    • NEJM 1993;329:977. The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
  • UKPDS (UK Prospective Diabetes Study)
    • Lancet 1998;352:837. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • Type 2 DM
  • Effects on macroangiopathy (cardiovascular disease and atherosclerosis) are less certain